Differential methylation EPIC analysis discloses cisplatin-resistance related hypermethylation and tumor-specific heterogeneity within matched primary and metastatic testicular germ cell tumor patient tissue samples

Testicular germ cell tumors (TGCTs) are among the most common solid malignancies in young-adult men, and currently most mortality is due to metastatic disease and emergence of resistance to cisplatin. There is some evidence that increased methylation is one mechanism behind this resistance, stemming...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Lobo, João, Constâncio, Vera, Leite-Silva, Pedro, Guimarães, Rita, Cantante, Mariana, Braga, Isaac, Maurício, Joaquina, Looijenga, Leendert H. J., Henrique, Rui, Jerónimo, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025580/
https://ncbi.nlm.nih.gov/pubmed/33823933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-021-01048-y
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