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Insert L1 is a central hub for allosteric regulation of USP1 activity
During DNA replication, the deubiquitinating enzyme USP1 limits the recruitment of translesion polymerases by removing ubiquitin marks from PCNA to allow specific regulation of the translesion synthesis (TLS) pathway. USP1 activity depends on an allosteric activator, UAF1, and this is tightly contro...
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| Izdano u: | EMBO Rep |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8024992/ https://ncbi.nlm.nih.gov/pubmed/33619839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051749 |
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