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Insert L1 is a central hub for allosteric regulation of USP1 activity
During DNA replication, the deubiquitinating enzyme USP1 limits the recruitment of translesion polymerases by removing ubiquitin marks from PCNA to allow specific regulation of the translesion synthesis (TLS) pathway. USP1 activity depends on an allosteric activator, UAF1, and this is tightly contro...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8024992/ https://ncbi.nlm.nih.gov/pubmed/33619839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051749 |
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