Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages

BACKGROUND & AIMS: Cancer-associated fibroblasts (CAFs) from pancreatic adenocarcinoma (PDA) present high protein synthesis rates. CAFs express the G-protein–coupled somatostatin receptor sst1. The sst1 agonist SOM230 blocks CAF protumoral features in vitro and in immunocompromised mice. We have...

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Bibliografiske detaljer
Udgivet i:Cell Mol Gastroenterol Hepatol
Main Authors: Samain, Rémi, Brunel, Alexia, Douché, Thibault, Fanjul, Marjorie, Cassant-Sourdy, Stéphanie, Rochotte, Julia, Cros, Jérôme, Neuzillet, Cindy, Raffenne, Jérôme, Duluc, Camille, Perraud, Aurélie, Nigri, Jérémy, Gigoux, Véronique, Bieche, Ivan, Ponzo, Matteo, Carpentier, Gilles, Cascone, Ilaria, Tomasini, Richard, Schmid, Herbert A., Mathonnet, Muriel, Nicolle, Rémy, Bousquet, Marie-Pierre, Martineau, Yvan, Pyronnet, Stéphane, Jean, Christine, Bousquet, Corinne
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024982/
https://ncbi.nlm.nih.gov/pubmed/33482394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.01.008
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