Acquired small cell lung cancer resistance to Chk1 inhibitors involves Wee1 up‐regulation

Platinum‐based chemotherapy has been the cornerstone treatment for small cell lung cancer (SCLC) for decades, but no major progress has been made in the past 20 years with regard to overcoming chemoresistance. As the cell cycle checkpoint kinase 1 (Chk1) plays a key role in DNA damage response to ch...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Zhao, Xiaoliang, Kim, In‐Kyu, Kallakury, Bhaskar, Chahine, Joeffrey J., Iwama, Eiji, Pierobon, Mariaelena, Petricoin, Emanuel, McCutcheon, Justine N., Zhang, Yu‐Wen, Umemura, Shigeki, Chen, Vincent, Wang, Changli, Giaccone, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024728/
https://ncbi.nlm.nih.gov/pubmed/33320980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12882
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