DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair

DNA ligase I (LIG1) completes the base excision repair (BER) pathway at the last nick-sealing step after DNA polymerase (pol) β gap-filling DNA synthesis. However, the mechanism by which LIG1 fidelity mediates the faithful substrate–product channeling and ligation of repair intermediates at the fina...

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Vydáno v:J Biol Chem
Hlavní autoři: Kamble, Pradnya, Hall, Kalen, Chandak, Mahesh, Tang, Qun, Çağlayan, Melike
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024709/
https://ncbi.nlm.nih.gov/pubmed/33600799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100427
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