Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is associated with epilepsy. However, its molecular functi...

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Publicado no:iScience
Main Authors: Kusuluri, Deva K., Güler, Baran E., Knapp, Barbara, Horn, Nicola, Boldt, Karsten, Ueffing, Marius, Aust, Gabriela, Wolfrum, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024656/
https://ncbi.nlm.nih.gov/pubmed/33851099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102283
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