C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells

Glioblastoma (GBM) is the most aggressive tumor from the central nervous system (CNS). The current lack of efficient therapies makes essential to find new treatment strategies. C3G, a guanine nucleotide exchange factor for some Ras proteins, plays a dual role in cancer, but its function in GBM remai...

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Publicat a:Cell Death Dis
Autors principals: Manzano, Sara, Gutierrez-Uzquiza, Alvaro, Bragado, Paloma, Sequera, Celia, Herranz, Óscar, Rodrigo-Faus, María, Jauregui, Patricia, Morgner, Stephanie, Rubio, Ignacio, Guerrero, Carmen, Porras, Almudena
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024353/
https://ncbi.nlm.nih.gov/pubmed/33824275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03631-w
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