Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase

[Image: see text] Structural information is crucial for understanding catalytic mechanisms and to guide enzyme engineering efforts of biocatalysts, such as terpene cyclases. However, low sequence similarity can impede homology modeling, and inherent protein instability presents challenges for struct...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Schriever, Karen, Saenz-Mendez, Patricia, Rudraraju, Reshma Srilakshmi, Hendrikse, Natalie M., Hudson, Elton P., Biundo, Antonino, Schnell, Robert, Syrén, Per-Olof
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2021
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023661/
https://ncbi.nlm.nih.gov/pubmed/33496585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10214
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