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Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase
[Image: see text] Structural information is crucial for understanding catalytic mechanisms and to guide enzyme engineering efforts of biocatalysts, such as terpene cyclases. However, low sequence similarity can impede homology modeling, and inherent protein instability presents challenges for struct...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2021
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8023661/ https://ncbi.nlm.nih.gov/pubmed/33496585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10214 |
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