Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-Immunotherapy in Multiple Solid Tumors

We developed a custom-designed liposome carrier for co-delivery of a potent immunogenic cell death (ICD) stimulus plus an inhibitor of the indoleamine 2,3-dioxygenase (IDO-1) pathway to establish a chemo-immunotherapy approach for solid tumors in syngeneic mice. The carrier was constructed by remote...

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Pubblicato in:ACS Nano
Autori principali: Mei, Kuo-Ching, Liao, Yu-Pei, Jiang, Jinhong, Chiang, Michelle, Khazaieli, Mercedeh, Liu, Xiangsheng, Wang, Xiang, Liu, Qi, Chang, Chong Hyun, Zhang, Xiao, Li, Juan, Ji, Ying, Melano, Brenda, Telesca, Donatello, Xia, Tian, Meng, Huan, Nel, Andre E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023019/
https://ncbi.nlm.nih.gov/pubmed/32940463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.0c05194
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