Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver

Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 (MBOAT7). To elucidate the link between these variants and fatty liver disease, we characterized Mboat7 liver-specific K...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Xia, Mingfeng, Chandrasekaran, Preethi, Rong, Shunxing, Fu, Xiaorong, Mitsche, Matthew A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022244/
https://ncbi.nlm.nih.gov/pubmed/32859645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000856
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