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Induced pluripotent stem cell reprogramming-associated methylation at the GABRA2 promoter and chr4p12 GABA(A) subunit gene expression in the context of alcohol use disorder

Twin studies indicate that there is a significant genetic contribution to the risk of developing alcohol use disorder (AUD). With the exception of coding variants in ADH1B and ALDH2, little is known about the molecular effects of AUD-associated loci. We previously reported that the AUD-associated sy...

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Detalhes bibliográficos
Publicado no:Am J Med Genet B Neuropsychiatr Genet
Main Authors: Goetjen, Alexandra, Watson, Maegan, Lieberman, Richard, Clinton, Kaitlin, Kranzler, Henry R., Covault, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022112/
https://ncbi.nlm.nih.gov/pubmed/33029895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.b.32824
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