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Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures

BACKGROUND: There is growing evidence that the anticonvulsant topiramate is efficacious in reducing alcohol consumption. Further, an intronic single nucleotide polymorphism (rs2832407, C ➔ A) in the GRIK1 gene, which encodes the GluK1 subunit of the excitatory kainate receptor, predicted topiramate’...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Alcohol Clin Exp Res
Prif Awduron: Lieberman, Richard, Jensen, Kevin P., Clinton, Kaitlin, Levine, Eric S., Kranzler, Henry R., Covault, Jonathan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491603/
https://ncbi.nlm.nih.gov/pubmed/32574382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.14399
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