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Tet1 Deficiency Leads to Premature Ovarian Failure
Tet enzymes participate in DNA demethylation and play critical roles in stem cell pluripotency and differentiation. DNA methylation alters with age. We find that Tet1 deficiency reduces fertility and leads to accelerated reproductive failure with age. Noticeably, Tet1-deficient mice at young age exh...
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| 出版年: | Front Cell Dev Biol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8021788/ https://ncbi.nlm.nih.gov/pubmed/33834024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.644135 |
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