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Tet1 Deficiency Leads to Premature Ovarian Failure
Tet enzymes participate in DNA demethylation and play critical roles in stem cell pluripotency and differentiation. DNA methylation alters with age. We find that Tet1 deficiency reduces fertility and leads to accelerated reproductive failure with age. Noticeably, Tet1-deficient mice at young age exh...
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| 發表在: | Front Cell Dev Biol |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Frontiers Media S.A.
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8021788/ https://ncbi.nlm.nih.gov/pubmed/33834024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.644135 |
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