Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation

Ten-eleven translocation (Tet) enzymes are involved in DNA demethylation, important in regulating embryo development, stem cell pluripotency and tumorigenesis. Alterations of DNA methylation with age have been shown in various somatic cell types. We investigated whether Tet1 and Tet2 regulate aging....

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:iScience
Autors principals: Huang, Guian, Liu, Linlin, Wang, Huasong, Gou, Mo, Gong, Peng, Tian, Chenglei, Deng, Wei, Yang, Jiao, Zhou, Tian-Tian, Xu, Guo-Liang, Liu, Lin
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049665/
https://ncbi.nlm.nih.gov/pubmed/32114381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100908
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars