Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation

Ten-eleven translocation (Tet) enzymes are involved in DNA demethylation, important in regulating embryo development, stem cell pluripotency and tumorigenesis. Alterations of DNA methylation with age have been shown in various somatic cell types. We investigated whether Tet1 and Tet2 regulate aging....

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Veröffentlicht in:iScience
Hauptverfasser: Huang, Guian, Liu, Linlin, Wang, Huasong, Gou, Mo, Gong, Peng, Tian, Chenglei, Deng, Wei, Yang, Jiao, Zhou, Tian-Tian, Xu, Guo-Liang, Liu, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049665/
https://ncbi.nlm.nih.gov/pubmed/32114381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100908
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