Reversible cardiac disease features in an inducible CUG repeat RNA–expressing mouse model of myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is caused by a CTG repeat expansion in the DMPK gene. Expression of pathogenic expanded CUG repeat (CUGexp) RNA causes multisystemic disease by perturbing the functions of RNA-binding proteins, resulting in expression of fetal protein isoforms in adult tissues. Cardia...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Rao, Ashish N., Campbell, Hannah M., Guan, Xiangnan, Word, Tarah A., Wehrens, Xander H.T., Xia, Zheng, Cooper, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021116/
https://ncbi.nlm.nih.gov/pubmed/33497365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143465
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