Discovery and in-vitro evaluation of potent SARS-CoV-2 entry inhibitors

SARS-CoV-2 infection initiates with the attachment of spike protein to the ACE2 receptor. While vaccines have been developed, no SARS-CoV-2 specific small molecule inhibitors have been approved. Herein, utilizing the crystal structure of the ACE2/Spike receptor binding domain (S-RBD) complex in comp...

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Publicat a:bioRxiv
Autors principals: Acharya, Arpan, Pandey, Kabita, Thurman, Michellie, Klug, Elizabeth, Trivedi, Jay, Lorson, Christian L., Singh, Kamal, Byrareddy, Siddappa N.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020965/
https://ncbi.nlm.nih.gov/pubmed/33821265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.02.438204
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