Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since doxycycline impacts α-synuclein aggregation and tox...

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Vydáno v:Front Aging Neurosci
Hlavní autoři: Medina, Luciana, González-Lizárraga, Florencia, Dominguez-Meijide, Antonio, Ploper, Diego, Parrales, Valeria, Sequeira, Sabrina, Cima-Omori, Maria-Sol, Zweckstetter, Markus, Del Bel, Elaine, Michel, Patrick P., Outeiro, Tiago Fleming, Raisman-Vozari, Rita, Chehín, Rosana, Socias, Sergio B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020845/
https://ncbi.nlm.nih.gov/pubmed/33828477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.635760
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