Vaccination Induces Maturation in a Mouse Model of Diverse Unmutated VRC01-Class Precursors to HIV-Neutralizing Antibodies with >50% Breadth

Vaccine elicitation of broadly neutralizing antibodies (bnAbs) is a key HIV-research goal. The VRC01-class of bnAbs targets the CD4-binding site on the HIV-envelope trimer and requires extensive somatic hypermutation to neutralize effectively. Despite substantial progress, vaccine-induced VRC01-clas...

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Publicado no:Immunity
Main Authors: Chen, Xuejun, Zhou, Tongqing, Schmidt, Stephen D., Duan, Hongying, Cheng, Cheng, Chuang, Gwo-Yu, Gu, Ying, Louder, Mark K., Lin, Bob C., Shen, Chen-Hsiang, Sheng, Zizhang, Zheng, Michelle X., Doria-Rose, Nicole A., Joyce, M. Gordon, Shapiro, Lawrence, Tian, Ming, Alt, Frederick W., Kwong, Peter D., Mascola, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020832/
https://ncbi.nlm.nih.gov/pubmed/33453152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.12.014
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