Rescue of codon-pair deoptimized respiratory syncytial virus by the emergence of genomes with very large internal deletions that complemented replication

Recoding viral genomes by introducing numerous synonymous but suboptimal codon pairs—called codon-pair deoptimization (CPD)—provides new types of live-attenuated vaccine candidates. The large number of nucleotide changes resulting from CPD should provide genetic stability to the attenuating phenotyp...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Le Nouën, Cyril, McCarty, Thomas, Yang, Lijuan, Brown, Michael, Wimmer, Eckard, Collins, Peter L., Buchholz, Ursula J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2021
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020775/
https://ncbi.nlm.nih.gov/pubmed/33753491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020969118
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