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Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization
Codon pair bias deoptimization (CPBD) has enabled highly efficient and rapid attenuation of RNA viruses. The technique relies on recoding of viral genes by increasing the number of codon pairs that are statistically underrepresented in protein coding genes of the viral host without changing the amin...
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| Pubblicato in: | PLoS Pathog |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5805365/ https://ncbi.nlm.nih.gov/pubmed/29377958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006857 |
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