Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

Codon pair bias deoptimization (CPBD) has enabled highly efficient and rapid attenuation of RNA viruses. The technique relies on recoding of viral genes by increasing the number of codon pairs that are statistically underrepresented in protein coding genes of the viral host without changing the amin...

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Udgivet i:PLoS Pathog
Main Authors: Eschke, Kathrin, Trimpert, Jakob, Osterrieder, Nikolaus, Kunec, Dusan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805365/
https://ncbi.nlm.nih.gov/pubmed/29377958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006857
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