Physiologically-based pharmacokinetic model for clozapine in Korean patients with schizophrenia

Clozapine has been used as a treatment of schizophrenia. Despite its large interindividual variability, few reports addressed the physiologically-based pharmacokinetic modeling and simulation (PBPK M&S) of clozapine in patients. This study aimed to develop a PBPK M&S of clozapine in Korean p...

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Bibliographic Details
Published in:Transl Clin Pharmacol
Main Authors: Lee, Joomi, Kim, Min-Gul, Jeong, Hyeon-Cheol, Shin, Kwang-Hee
Format: Artigo
Language:Inglês
Published: Korean Society for Clinical Pharmacology and Therapeutics 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020364/
https://ncbi.nlm.nih.gov/pubmed/33854999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2021.29.e3
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