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The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling

BACKGROUND AND OBJECTIVES: Physiologically based pharmacokinetic (PBPK) modeling permits clinical scientists to reduce practical constraints for clinical trials on patients with special diseases. In this study, simulations were carried out to validate the pharmacokinetic parameters of clozapine and...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Ghoneim, Amira M, Mansour, Suzan M
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166056/
https://ncbi.nlm.nih.gov/pubmed/32341640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S246229
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