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The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling
BACKGROUND AND OBJECTIVES: Physiologically based pharmacokinetic (PBPK) modeling permits clinical scientists to reduce practical constraints for clinical trials on patients with special diseases. In this study, simulations were carried out to validate the pharmacokinetic parameters of clozapine and...
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| Pubblicato in: | Drug Des Devel Ther |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Dove
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7166056/ https://ncbi.nlm.nih.gov/pubmed/32341640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S246229 |
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