Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice

We tested the hypothesis that voluntary wheel running would complement microdystrophin gene therapy to improve muscle function in young mdx mice, a model of Duchenne muscular dystrophy. mdx mice injected with a single dose of AAV9-CK8-microdystrophin or vehicle at age 7 weeks were assigned to three...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Hamm, Shelby E., Fathalikhani, Daniel D., Bukovec, Katherine E., Addington, Adele K., Zhang, Haiyan, Perry, Justin B., McMillan, Ryan P., Lawlor, Michael W., Prom, Mariah J., Vanden Avond, Mark A., Kumar, Suresh N., Coleman, Kirsten E., Dupont, J.B., Mack, David L., Brown, David A., Morris, Carl A., Gonzalez, J. Patrick, Grange, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020351/
https://ncbi.nlm.nih.gov/pubmed/33850950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.024
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