Sec22b determines Weibel-Palade body length by controlling anterograde endoplasmic reticulum-Golgi transport

Von Willebrand factor (VWF) is a multimeric hemostatic protein that is synthesized in endothelial cells, where it is stored for secretion in elongated secretory organelles called Weibel-Palade bodies (WPB). The hemostatic activity of VWF is strongly related to the length of these bodies, but how end...

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Bibliographic Details
Published in:Haematologica
Main Authors: Karampini, Ellie, Bürgisser, Petra E., Olins, Jenny, Mulder, Aat A., Jost, Carolina R., Geerts, Dirk, Voorberg, Jan, Bierings, Ruben
Format: Artigo
Language:Inglês
Published: Fondazione Ferrata Storti 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018124/
https://ncbi.nlm.nih.gov/pubmed/32336681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.242727
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