Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration

Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclusively in the nucleus at the genomic integration s...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fukuda, Shinichi, Varshney, Akhil, Fowler, Benjamin J., Wang, Shao-bin, Narendran, Siddharth, Ambati, Kameshwari, Yasuma, Tetsuhiro, Magagnoli, Joseph, Leung, Hannah, Hirahara, Shuichiro, Nagasaka, Yosuke, Yasuma, Reo, Apicella, Ivana, Pereira, Felipe, Makin, Ryan D., Magner, Eamonn, Liu, Xinan, Sun, Jian, Wang, Mo, Baker, Kirstie, Marion, Kenneth M., Huang, Xiwen, Baghdasaryan, Elmira, Ambati, Meenakshi, Ambati, Vidya L., Pandey, Akshat, Pandya, Lekha, Cummings, Tammy, Banerjee, Daipayan, Huang, Peirong, Yerramothu, Praveen, Tolstonog, Genrich V., Held, Ulrike, Erwin, Jennifer A., Paquola, Apua C. M., Herdy, Joseph R., Ogura, Yuichiro, Terasaki, Hiroko, Oshika, Tetsuro, Darwish, Shaban, Singh, Ramendra K., Mozaffari, Saghar, Bhattarai, Deepak, Kim, Kyung Bo, Hardin, James W., Bennett, Charles L., Hinton, David R., Hanson, Timothy E., Röver, Christian, Parang, Keykavous, Kerur, Nagaraj, Liu, Jinze, Werner, Brian C., Sutton, S. Scott, Sadda, Srinivas R., Schumann, Gerald G., Gelfand, Bradley D., Gage, Fred H., Ambati, Jayakrishna
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017980/
https://ncbi.nlm.nih.gov/pubmed/33526699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022751118
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