A novel combination regimen of BET and FLT3 inhibition for FLT3-ITD acute myeloid leukemia

Acute myeloid leukemia (AML) patients with FLT3-ITD mutations have a high risk of relapse and death. FLT3 tyrosine kinase inhibitors improve overall survival, but their efficacy is limited and most patients who relapse will ultimately die of the disease. Even with potent FLT3 inhibition, the disease...

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Veröffentlicht in:Haematologica
Hauptverfasser: Lee, Lauren Y., Hizukuri, Yoshiyuki, Severson, Paul, Powell, Benjamin, Zhang, Chao, Ma, Yan, Narahara, Maiko, Sumi, Hiroyuki, Hernandez, Daniela, Rajkhowa, Trivikram, Bollag, Gideon, Levis, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: Fondazione Ferrata Storti 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017818/
https://ncbi.nlm.nih.gov/pubmed/33504139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2020.247346
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