Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro

Aptazyme and CRISPR/Cas gene editing system were widely used for regulating gene expression in various diseases, including cancer. This work aimed to reconstruct CRISPR/Cas13d tool for sensing hTERT exclusively based on the new device OFF-switch hTERT aptazyme that was inserted into the 3’ UTR of th...

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Publicat a:Front Mol Biosci
Autors principals: Zhuang, Chengle, Zhuang, Changshui, Zhou, Qun, Huang, Xueting, Gui, Yaoting, Lai, Yongqing, Yang, Shangqi
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Molecular Biosciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017217/
https://ncbi.nlm.nih.gov/pubmed/33816560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.646412
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