miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a

Compromised cardiac function is a hallmark for heart failure, mostly appearing as decreased contractile capacity due to dysregulated calcium handling. Unfortunately, the underlying mechanism causing impaired calcium handling is still not fully understood. Previously the miR-132/212 family was identi...

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Bibliographic Details
Published in:Front Cardiovasc Med
Main Authors: Lei, Zhiyong, Wahlquist, Christine, el Azzouzi, Hamid, Deddens, Janine C., Kuster, Diederik, van Mil, Alain, Rojas-Munoz, Agustin, Huibers, Manon M., Mercola, Mark, de Weger, Roel, Van der Velden, Jolanda, Xiao, Junjie, Doevendans, Pieter A., Sluijter, Joost P. G.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Cardiovascular Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017124/
https://ncbi.nlm.nih.gov/pubmed/33816571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.592362
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