Phase 1B Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck

PURPOSE: Based on synergistic effects between green tea polyphenon E (PPE) and epidermal growth factor receptor-tyrosine kinase inhibitor in preclinical studies, we conducted a phase 1b study of the PPE and erlotinib combination in patients with advanced premalignant lesions (APL) of the oral cavity...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Shin, Dong M., Nannapaneni, Sreenivas, Patel, Mihir, Shi, Quiying, Liu, Yuan, Chen, Zhengjia, Chen, Amy, El-Deiry, Mark W., Beitler, Jonathan J., Steuer, Conor, Roser, Steven, Klein, Adam M., Owonikoko, Taofeek, Ramalingam, Suresh, Khuri, Fadlo R., Chen, Zhuo G., Saba, Nabil F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016407/
https://ncbi.nlm.nih.gov/pubmed/32943457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2276
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