Baricitinib restrains the immune dysregulation in patients with severe COVID-19

BACKGROUND: Patients with coronavirus disease 2019 (COVID-19) develop pneumonia generally associated with lymphopenia and a severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK/STAT signaling pathways, which can be disabled by...

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Pubblicato in:J Clin Invest
Autori principali: Bronte, Vincenzo, Ugel, Stefano, Tinazzi, Elisa, Vella, Antonio, De Sanctis, Francesco, Canè, Stefania, Batani, Veronica, Trovato, Rosalinda, Fiore, Alessandra, Petrova, Varvara, Hofer, Francesca, Barouni, Roza Maria, Musiu, Chiara, Caligola, Simone, Pinton, Laura, Torroni, Lorena, Polati, Enrico, Donadello, Katia, Friso, Simonetta, Pizzolo, Francesca, Iezzi, Manuela, Facciotti, Federica, Pelicci, Pier Giuseppe, Righetti, Daniela, Bazzoni, Paolo, Rampudda, Mariaelisa, Comel, Andrea, Mosaner, Walter, Lunardi, Claudio, Olivieri, Oliviero
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016181/
https://ncbi.nlm.nih.gov/pubmed/32809969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141772
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