Baricitinib restrains the immune dysregulation in patients with severe COVID-19

BACKGROUND: Patients with coronavirus disease 2019 (COVID-19) develop pneumonia generally associated with lymphopenia and a severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK/STAT signaling pathways, which can be disabled by...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bronte, Vincenzo, Ugel, Stefano, Tinazzi, Elisa, Vella, Antonio, De Sanctis, Francesco, Canè, Stefania, Batani, Veronica, Trovato, Rosalinda, Fiore, Alessandra, Petrova, Varvara, Hofer, Francesca, Barouni, Roza Maria, Musiu, Chiara, Caligola, Simone, Pinton, Laura, Torroni, Lorena, Polati, Enrico, Donadello, Katia, Friso, Simonetta, Pizzolo, Francesca, Iezzi, Manuela, Facciotti, Federica, Pelicci, Pier Giuseppe, Righetti, Daniela, Bazzoni, Paolo, Rampudda, Mariaelisa, Comel, Andrea, Mosaner, Walter, Lunardi, Claudio, Olivieri, Oliviero
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016181/
https://ncbi.nlm.nih.gov/pubmed/32809969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141772
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