TCR(+)/BCR(+) dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes

Ahmed and colleagues recently described a novel hybrid lymphocyte expressing both a B and T cell receptor, termed double expresser (DE) cells. DE cells in blood of T1D subjects were present at increased numbers and enriched for a public B cell clonotype. Here, we attempted to reproduce these finding...

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Pubblicato in:Cell
Autori principali: Japp, Alberto Sada, Meng, Wenzhao, Rosenfeld, Aaron M., Perry, Daniel J., Thirawatananond, Puchong, Bacher, Rhonda L., Liu, Chengyang, Gardner, Jay S., Atkinson, Mark A., Kaestner, Klaus H., Brusko, Todd M., Naji, Ali, Luning Prak, Eline T., Betts, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016147/
https://ncbi.nlm.nih.gov/pubmed/33545036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.035
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