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A Reply to “TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes”
We have recently identified a novel lymphocyte that is a dual expresser (DE) of TCRαβ and BCR. DEs in T1D patients are predominated by a public BCR clonotype (clone-x) that encodes a potent autoantigen that cross-activates insulin-reactive T cells. Betts and colleagues were able to detect DEs, but a...
Uloženo v:
| Vydáno v: | Cell |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7935028/ https://ncbi.nlm.nih.gov/pubmed/33545037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.036 |
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