Mitochondrial Pyruvate Carriers are Required for Myocardial Stress Adaptation

In addition to fatty acids, glucose and lactate are important myocardial substrates under physiological and stress conditions. They are metabolized to pyruvate that enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle (CAC) metabolism. Here, we show that MPC-mediate...

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Pubblicato in:Nat Metab
Autori principali: Zhang, Yuan, Taufalele, Paul V, Cochran, Jesse D, Frayne, Isabelle Robillard, Marx, Jonas Maximilian, Soto, Jamie, Rauckhorst, Adam J, Tayyari, Fariba, Pewa, Alvin D, Gray, Lawrence R, Teesch, Lynn M, Puchalska, Patrycja, Funari, Trevor R., McGlauflin, Rose, Zimmerman, Kathy, Kutschke, William J., Cassier, Thomas, Hitchcock, Shannon, Lin, Kevin, Kato, Kevin M., Stueve, Jennifer L., Haff, Lauren, Weiss, Robert M., Cox, James E., Rutter, Jared, Taylor, Eric B., Crawford, Peter A., Lewandowski, E. Douglas, Des Rosiers, Christine, Abel, E. Dale
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015649/
https://ncbi.nlm.nih.gov/pubmed/33106689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-00288-1
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