Mitochondrial Pyruvate Carriers are Required for Myocardial Stress Adaptation

In addition to fatty acids, glucose and lactate are important myocardial substrates under physiological and stress conditions. They are metabolized to pyruvate that enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle (CAC) metabolism. Here, we show that MPC-mediate...

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Publicado no:Nat Metab
Main Authors: Zhang, Yuan, Taufalele, Paul V, Cochran, Jesse D, Frayne, Isabelle Robillard, Marx, Jonas Maximilian, Soto, Jamie, Rauckhorst, Adam J, Tayyari, Fariba, Pewa, Alvin D, Gray, Lawrence R, Teesch, Lynn M, Puchalska, Patrycja, Funari, Trevor R., McGlauflin, Rose, Zimmerman, Kathy, Kutschke, William J., Cassier, Thomas, Hitchcock, Shannon, Lin, Kevin, Kato, Kevin M., Stueve, Jennifer L., Haff, Lauren, Weiss, Robert M., Cox, James E., Rutter, Jared, Taylor, Eric B., Crawford, Peter A., Lewandowski, E. Douglas, Des Rosiers, Christine, Abel, E. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015649/
https://ncbi.nlm.nih.gov/pubmed/33106689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-00288-1
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