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Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

Epidemiological research has shown that elevated serum urate concentration is a risk factor for the development of kidney disease; however, the mechanisms underlying this process have not yet been elucidated. To examine the role of urate in the kidney, we used Wistar rats to functionally disrupt exp...

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Publicado en:Dis Model Mech
Autores principales: Wu, Mian, Ma, Yiwen, Chen, Xiaoting, Liang, Nan, Qu, Shen, Chen, Haibing
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015218/
https://ncbi.nlm.nih.gov/pubmed/33648977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.048041
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