Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease

Core spliceosome and related RNA-binding proteins aggregate in Alzheimer’s disease (AD) brain even in early asymptomatic stages (AsymAD) of disease. To assess the specificity of RNA-binding protein aggregation in AD, we developed a targeted mass spectrometry approach to quantify broad classes of RNA...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Guo, Qi, Dammer, Eric B., Zhou, Maotian, Kundinger, Sean R., Gearing, Marla, Lah, James J., Levey, Allan I., Shulman, Joshua M., Seyfried, Nicholas T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8014091/
https://ncbi.nlm.nih.gov/pubmed/33815056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2021.623659
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