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Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes

Lipid carriers of hydrophobic paclitaxel (PTX) are used in clinical trials for cancer chemotherapy. Improving their loading capacity requires enhanced PTX solubilization. We compared the time-dependence of PTX membrane solubility as a function of PTX content in cationic liposomes (CLs) with lipid ta...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Zhen, Yuhong, Ewert, Kai K., Fisher, William S., Steffes, Victoria M., Li, Youli, Safinya, Cyrus R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012651/
https://ncbi.nlm.nih.gov/pubmed/33790325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86484-9
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