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PEGylation of paclitaxel-loaded cationic liposomes drives steric stabilization of bicelles and vesicles thereby enhancing delivery and cytotoxicity to human cancer cells

Polyethylene glycol (PEG) is a polymer used widely in drug delivery to create “stealth” nanoparticles (NPs); PEG coatings suppress NP detection and clearance by the immune system and beneficially increase NP circulation time in vivo. However, NP PEGylation typically obstructs cell attachment and upt...

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Detalhes bibliográficos
Publicado no:ACS Appl Mater Interfaces
Main Authors: Steffes, Victoria M., Zhang, Zhening, MacDonald, Scott, Crowe, John, Ewert, Kai K., Carragher, Bridget, Potter, Clinton S., Safinya, Cyrus R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984750/
https://ncbi.nlm.nih.gov/pubmed/31820904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsami.9b16150
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