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NMDAR-independent, cAMP-dependent antidepressant actions of ketamine

Ketamine produces rapid and robust antidepressant effects in depressed patients within hours of administration, often when traditional antidepressant compounds have failed to alleviate symptoms. We hypothesized that ketamine would translocate Gα(s) from lipid rafts to non-raft microdomains, similarl...

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Publicado en:Mol Psychiatry
Main Authors: Wray, Nathan H., Schappi, Jeffrey M., Singh, Harinder, Senese, Nicolas B., Rasenick, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011999/
https://ncbi.nlm.nih.gov/pubmed/29895894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0083-8
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