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Disruption of lipid-raft localized Gα(s)/tubulin complexes by antidepressants: a unique feature of HDAC6 inhibitors, SSRI and tricyclic compounds

Current antidepressant therapies meet with variable therapeutic success and there is increasing interest in therapeutic approaches not based on monoamine signaling. Histone deacetylase 6 (HDAC6), which also deacetylates α-tubulin shows altered expression in mood disorders and HDAC6 knockout mice mim...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Singh, Harinder, Wray, Nathan, Schappi, Jeffrey M., Rasenick, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983546/
https://ncbi.nlm.nih.gov/pubmed/29463911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0016-x
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