Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma

The chemokine system plays an important role in mediating a proinflammatory microenvironment for tumor growth in hepatocellular carcinoma (HCC). The CXCR6 receptor and its natural ligand CXCL16 are expressed at high levels in HCC cell lines and tumor tissues and receptor expression correlates with i...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Peddibhotla, Satyamaheshwar, Hershberger, Paul M., Kirby, R. Jason, Sugarman, Eliot, Maloney, Patrick R., Sessions, E. Hampton, Divlianska, Daniela, Morfa, Camilo J., Terry, David, Pinkerton, Anthony B., Smith, Layton H., Malany, Siobhan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011643/
https://ncbi.nlm.nih.gov/pubmed/31882297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126899
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