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The nucleotide addition cycle of the SARS-CoV-2 polymerase

Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit (nsp12) and its intimately associated cofactors (nsp7 and nsp8). We have used a high-throughput magnetic-tweezers approach to d...

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Bibliographische Detailangaben
Veröffentlicht in:bioRxiv
Hauptverfasser: Bera, Subhas Chandra, Seifert, Mona, Kirchdoerfer, Robert N., van Nies, Pauline, Wubulikasimu, Yibulayin, Quack, Salina, Papini, Flávia S., Arnold, Jamie J., Canard, Bruno, Cameron, Craig E., Depken, Martin, Dulin, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010733/
https://ncbi.nlm.nih.gov/pubmed/33791706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.27.437309
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