Influence of the Circadian Timing System on Tacrolimus Pharmacokinetics and Pharmacodynamics After Kidney Transplantation

Introduction: Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient pharmacokinetic variability leading to frequent over- and under-immunosuppression. While routine therapeutic drug monitoring (T...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Fontova, Pere, Colom, Helena, Rigo-Bonnin, Raül, van Merendonk, Lisanne N., Vidal-Alabró, Anna, Montero, Nuria, Melilli, Edoardo, Meneghini, Maria, Manonelles, Anna, Cruzado, Josep M., Torras, Juan, Grinyó, Josep Maria, Bestard, Oriol, Lloberas, Nuria
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010682/
https://ncbi.nlm.nih.gov/pubmed/33815118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.636048
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