Influence of the Circadian Timing System on Tacrolimus Pharmacokinetics and Pharmacodynamics After Kidney Transplantation

Introduction: Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient pharmacokinetic variability leading to frequent over- and under-immunosuppression. While routine therapeutic drug monitoring (T...

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Vydáno v:Front Pharmacol
Hlavní autoři: Fontova, Pere, Colom, Helena, Rigo-Bonnin, Raül, van Merendonk, Lisanne N., Vidal-Alabró, Anna, Montero, Nuria, Melilli, Edoardo, Meneghini, Maria, Manonelles, Anna, Cruzado, Josep M., Torras, Juan, Grinyó, Josep Maria, Bestard, Oriol, Lloberas, Nuria
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010682/
https://ncbi.nlm.nih.gov/pubmed/33815118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.636048
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